Homozygote Prdx1−/− mice knockouts develop hemolytic anemia and several malignant cancers including epithelial and mesenchymal tumors such as hepatocellular carcinoma, fibrosarcoma, osteosarcoma, islet cell adenomas, and adenocarcinomas of the lung and breast [50]. The gene discussed is PRDX1; the disease is pancreatic insulinoma.