Homozygote Prdx1−/− mice knockouts develop hemolytic anemia and several malignant cancers including epithelial and mesenchymal tumors such as hepatocellular carcinoma, fibrosarcoma, osteosarcoma, islet cell adenomas, and adenocarcinomas of the lung and breast [50]. This evidence concerns the gene PRDX1 and mesenchymal cell neoplasm.