LRP1 and obesity due to melanocortin 4 receptor deficiency: Although LRP-1 has been shown to be upregulated in obese human adipose tissue [3], and increased concentrations of TGRL, such as chylomicron remnants, have been implicated in obesity in humans [7], this is the first study, to our knowledge, to report an association between LRP-1 variants and BMI in humans.