PINK1 and Parkinson disease: More recently, the Drosophila ortholog of mammalian PGAM5 (dPGAM5) has been shown to act as an exacerbating factor in the Drosophila model of Parkinson's disease induced by mutation of PTEN-induced kinase 1 (PINK1), a mitochondrial serine/threonine kinase known as a gene product responsible for early-onset autosomal recessive Parkinson's disease [11].