Deletions of ProSAP2/SHANK3 at chromosome 22q13 are one of the major genetic abnormalities in neurodevelopmental disorders [20], and mutations of ProSAP2/SHANK3 have been identified in patients with ASD, intellectual disability (ID) and schizophrenia [7], [23]–[25]. This evidence concerns the gene SHANK3 and neurodevelopmental disorder.