While there were 6 MESC CpGs (FCGR3B, FLJ27255, FCN2, KRT82, CDH13, KRTAP8-1 on chromosome 1, 6, 9, 12, 16 and 21 respectively) commonly hypomethylated at a frequency of at least 10% in all four cancers (P<10−4), there were substantially larger overlaps between related cancers such as ovarian and endometrial cancer (overlap of 98 CpGs, OR = 134, 95%CI = (89–205), P = 3.2×10−124). This evidence concerns the gene KRTAP8-1 and endometrial cancer.