Likewise, several seed genes for the ER network, including APPBP2, ASH2L, BAG4, CCND1, CLTC, DDX5, DEDD, EPN3, GPAA1, PHB, PRKAR1A, PRKDC, PSMC5, PTK2, RPS6KB1, SPOP, and YWHAZ were not significantly over- or under-expressed in ER+ cancers relative to other subtypes but showed copy number abnormalities. The gene discussed is SPOP; the disease is cancer.