CCL2 and Stroke: Evidence for the contribution of CCL2 to upstream cellular signaling during injury and repair shows that CCL2-CCR2 signaling upregulates transcription factors, including MCP-1-induced protein (MCPIP) [19] and Ets-1 [20], in monocytes and endothelial cells to initiate angiogenesis, a process that is critical to stroke recovery [21].