The most significantly downregulated gene sets included kidney transplant well UP [26], insulin 2F UP (genes 2 fold upregulated in muscle by insulin) [27], heartfailure atria DN, GH GHRHR KO 24 hrs DN [28], proteasome, and diab neph DN (genes downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy) (FWER < 0.05) (Table 2). The gene discussed is GHRHR; the disease is diabetic kidney disease.