In terms of the perception of frequency of hyperglycaemia/hypoglycaemia, patients in the insulin glargine group perceived a significantly greater reduction in the frequency of both hyperglycaemia and hypoglycaemia over the observational period following their switch from NPH insulin, than patients who remained on NPH insulin for the duration of the study (p < 0.0001). The gene discussed is INS; the disease is Hyperglycemia.