SHBG and breast cancer: Prediagnostic concentrations of testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS) and sex hormone-binding globulin (SHBG) were measured in serum samples from 356 incident cases and 683 controls who were premenopausal at enrollment (time of initial blood donation), and the association of these biomarkers with subsequent risk of breast cancer was assessed.