To analyze the disease-specificity of antibodies to these citrullinated FN peptides, sera from 31 multiple sclerosis (MS), 32 type 1 diabetes (T1D), 31 primary Sjőgren's syndrome (pSS), 31 systemic lupus erythematosus (SLE) and 29 tuberculosis (TB) patients, and from 32 healthy individuals, in parallel with 75 established RA sera, were analyzed by ELISA. This evidence concerns the gene FN1 and type 1 diabetes mellitus.