The fact that all HNSCC cell lines used in this study express no or only mutated p53 suggests that the physical interaction between MYBBP1A and p53 is not required for its opposing functions on tumor cell proliferation and migration, and it will be interesting to investigate the consequence of MYBBP1A over expression and silencing in primary keratinocytes as well as tumor cells with functional p53. This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.