In the dominant model, there was no evidence for an influence of XRCC1 399 A allele on overall survival of lung cancer patients (G/A and A/A vs. G/G: HR, 1.18; 95% CI, 0.93-1.50; P = 0.329 for heterogeneity, I2 = 10.2%) (Figure 4C). Here, XRCC1 is linked to lung cancer.