In particular, Jaeger et al. [51] reported that repeated systemic injections (3 times) of LPS increased Aβ accumulation in the brain through increased influx of blood Aβ contributed to alteration of LRP-1 in mice brain although it is different with our mechanism of amyloid deposition, and it supports our LPS-induced AD model. The gene discussed is LRP1; the disease is Alzheimer disease.