AKT1 and melanoma: Furthermore, we and others have shown that the elevation of insulin-like growth factor receptor (IGFR) or platelet-derived growth factor receptor (PDGFR) confer resistance to BRAFV600E inhibitors through activation of the PI3K/Akt signaling pathway (10-12), collectively suggesting that targeting of the PI3K/Akt signaling pathway along with the MAPK pathway might provide a new and more effective therapeutic approach for melanoma treatment.