However, some studies found no effects of moderate or even high doses (3.5 g fructose/kg fat-free mass/day) of fructose ingestion or infusion on serum/plasma levels of glucose, postprandial plasma glucose, glycated hemoglobin, glycosylated albumin, insulin and insulin sensitivity in healthy, lean, obese non-diabetic, obese or type 2 diabetic subjects [63,64,65]. Here, INS is linked to type 2 diabetes mellitus.