After adjusting for age, tumor cell differentiation, primary tumor status and lymph node metastasis using multivariate analysis, cyclin D1 overexpression was still associated with a significantly increased hazard ratio for DFS and OS, respectively, of 1.540 (95% CI, 1.068 - 2.222) and 1.702 (95% CI, 1.168 - 2.480) compared with the patients with tumors without cyclin D1 overexpression (Table 4). Here, CCND1 is linked to metastatic malignant neoplasm in the lymph nodes.