Intriguingly, the low miR-24:protein ratios in RB1+/+ retinoblastomas are consistent with the notion that, in the absence of selection pressure from ARF activation induced by RB1 loss, tumor cells may maximize proliferation through the derepression of MYC and E2F2 [21] without the compromise of tumor suppressor activation. The gene discussed is MYC; the disease is neoplasm.