As demonstrated previously (Figure 2B), IL-1β was detected in the supernatants of cultured PBMCs of patients with HAM/TSP; the release of IL-1β from these cultured HAM/TSP PBMCs was also inhibited by 10 μM of minocycline treatment (p = 0.0078; Figure 3B). The gene discussed is IL1B; the disease is tropical spastic paraparesis.