Studies with an antimouse PlGF antibody showed no effect on fetal development, hypertension, regression of healthy vessels, or increased risk of thrombosis in mice; thus, it is assumed that targeting PlGF will be devoid of the side effects associated with VEGF(R) inhibitors (Eskens and Verweij, 2006; Fischer et al, 2007). The gene discussed is PGF; the disease is hypertensive disorder.