SATB2 expression was lower in colon cancer with 101 out of 321 (31.5%) negative tumours compared with rectal cancer, where 46 out of 193 (23.8%) tumours were SATB2 negative, although this difference did not reach statistical significance (R=0.081, P=0.066). The gene discussed is SATB2; the disease is malignant colon neoplasm.