Wang et al (2009) also found an inverse association between SATB1 and SATB2 in CRC cells in vitro. In lung cancer, a significant loss of SATB1 expression was found in squamous preinvasive lesions and in non-small cell lung cancers compared with matched normal bronchial epithelium, and loss of SATB1 was an independent predictor of poor survival in squamous cell carcinomas (Selinger et al, 2010). Here, SATB1 is linked to colorectal carcinoma.