Furthermore, in light of the findings from several studies suggesting that 5-FU negatively affects outcome for microsatellite unstable tumours (Barratt et al, 2002; Ribic et al, 2003; Kim et al, 2007), the herein observed association between SATB2 expression and MSI status fits with the improved benefit from adjuvant treatment seen for patients with SATB2 high tumours. Here, SATB2 is linked to neoplasm.