A significant association between low SATB2 expression and metastatic CRC was, however, demonstrated in the study by Wang et al (2009), where ∼30% of the patients had M1 disease and the frequency of SATB2 low tumours was >50%, but as the proportion of tumours lacking SATB2 expression was not reported, comparisons are difficult to make. Here, SATB2 is linked to neoplasm.