SATB2 and lung cancer: Wang et al (2009) also found an inverse association between SATB1 and SATB2 in CRC cells in vitro. In lung cancer, a significant loss of SATB1 expression was found in squamous preinvasive lesions and in non-small cell lung cancers compared with matched normal bronchial epithelium, and loss of SATB1 was an independent predictor of poor survival in squamous cell carcinomas (Selinger et al, 2010).