Among the seven defined modules, proliferation (Wilcoxon test, P = 0.064), HER2 (Wilcoxon test, P = 0.0057), tumor invasion and metastasis (Wilcoxon test, P = 1.0 × 10-5), ER signaling (Wilcoxon test, P = 1.3 × 10-8) and immune response (Wilcoxon test, P = 0.16) displayed significant differences or a tendency towards differences between the two subgroups (Figure 2A). The gene discussed is ESR1; the disease is neoplasm.