The ACE DD genotype was reported to be associated with CAD risk in several studies including ECTIM [7], INSERM [8], ISIS [10] and CORGENE [28] cohorts, and subsequent studies revealed that the D allele or DD genotype may confer effects mainly on the onset of ACS or MI [29] by modifying ACE abundance or activity, and contributing to increases in plaque instability, ulceration and thrombosis [30]. Here, ACE is linked to coronary artery disorder.