MAPT and Insulin resistance: MGO may promote neuronal cell death by contributing directly to insulin resistance via acceleration of AGE formation [79], and also by involvement in the combined effects of dicarbonyl reactivity with tau, and hyperphosphorylation of tau and other proteins by protein O-glycosylation via monosaccharide β-N-acetylglucosamine attachment to serine/threonine residues via an O-linked glycosidic bond [80].