KSHV-specific T-cell responses appeared concurrent with clinical improvement in iatrogenic KS patients after a reduction of their immunosuppressive therapy or a conversion from calcineurin inhibitors (which block calcineurin-activated transcription of IL2) to sirolimus (also known as rapamycin, which acts through mTOR to inhibit responses to IL2) [29]. The gene discussed is IL2; the disease is Kaposi's sarcoma.