CD8A and neoplasm: To address whether low frequencies of KSHV-specific CD8 T cells in the peripheral blood of KS patients is due to recruitment of these cells to the site of the tumour, one group performed in situ tetramer staining, and confocal laser scanning microscopy on KS biopsy specimens from two patients who had detectable circulating KSHV-specific CD8 T cells at the time of biopsy.