To test our hypothesis, we evaluated the association between the g.32373708 G>A polymorphism (rs867469) of the IRP1 gene and the g.49520870 G>A (rs17483548) polymorphism of the IRP2 gene and AMD as well as the modulation of this association by some environmental and life-style factors. This evidence concerns the gene IREB2 and age-related macular degeneration.