C3 and age-related macular degeneration: AMD can be genetically associated with multiple susceptibility loci, i.a. 1q32 (complement factor H, CFH), 10q26 (ARMS2), 6p21.3 (complement factor B, BF; complement component 2, C2), 19p13.3–13.2 (complement component 3, C3) [55–61].