1 Since hypercholesterolaemia significantly decreased GPX activity in the present study, this probably resulted in aggregation of H2O2 and other reactive oxygen species and may have caused lipid peroxidation. It has also been reported that amlodipine reduced oxidative stress by restoring copper/zinc-containing SOD activity in the heart in hypertensive rats.34 This evidence concerns the gene SOD1 and Hypercholesterolemia.