SOD1 and atherosclerosis: It has been proposed that oxidative stress plays an important role in the inflammatory processes that are key components of atherosclerosis.8 Under physiological conditions, the toxic effects of ROS can be reduced by enzymatic and non-enzymatic antioxidants.9 Superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) provide the first line of enzymatic antioxidant defence against ROS-mediated cardiac injury.1,10