SOD1 and Hypercholesterolemia: It has been proposed that a high-cholesterol diet induces free radical production and may result in oxidative stress, which plays an important role in hypercholesterolaemia-induced atheroschelerosis.31 Our data showed that a high-cholesterol diet decreased antioxidant enzyme activity (SOD and GPX) in both blood and heart tissue, and also confirmed that amlodipine could decrease the activation of oxidative stress.