Interestingly, the kidney fibrosis [24-26,69], liver fibrosis [70,71], lung fibrosis [72-74], cardiac fibrosis [23,75,76] and peritoneal fibrosis [77] are found to be related to the expression of s100a4. Glässer's disease is characterized mainly by fibrinous polyserositis, meningitis, and arthritis. Here, S100A4 is linked to arthritic joint disease.