CCNE1 and serous adenocarcinoma: For example, high-grade serous carcinoma (type II tumor) is characterized by very frequent TP53 mutations (> 80% of cases) and CCNE1 (encoding cyclin E1) amplification but rarely has mutations that characterize most type 1 I tumors such as KRAS, BRAF, ERBB2, PTEN, CTNNB1, and PIK3CA [6].