The development of GLP-1 receptor agonists, such as Geniposide or Exendin-4, which harbor the same neuro-protective and neuro-stimulatory properties as GLP-1 [317], but have longer half-lives [311, 315, 318, 319], may provide effective and standardized long-term options for treating brain insulin resistance diseases such as AD. The gene discussed is GLP1R; the disease is Alzheimer disease.