This leads to the obvious conclusion that, in addition to multi-modal pharmaceutical targeting of brain insulin/IGF resistance, oxidative stress, inflammation [metal ion accumulation], and AβPP-Aβ and tau misfolding and fibrillarization, lifestyle measures could be effective in helping to prevent or delay the onset of aging-associated neurodegenerative diseases, including AD. Here, IGF1 is linked to neurodegenerative disease.