Mechanistically, SIRT1 functions by interfering with AβPP-Aβ peptide generation [433, 434], and SIRT1-activating molecules such as resveratrol, were shown to reduce neurodegeneration and prevent learning impairments in the p25 transgemic mouse model of AD, which is associated with tau hyper-phosphorylation and fibrillarization [435]. This evidence concerns the gene APP and Alzheimer disease.