Experimentally, lithium chloride treatment of Swedish AβPP transgenic mice reduced GSK-3β-induced AβPP-Aβ accumulation [292, 293], and treatment of mutant AβPP and tau double transgenic AD mice with the NP12 GSK-3 inhibitor, significantly reduced brain amyloid burden, tau alterations, and neuronal survival [294]. This evidence concerns the gene APP and Alzheimer disease.