GPT and chronic hepatitis B virus infection: As the efficacy of long-term follow-up is unknown for the combination therapy (Pegasys plus Entecavir) in chronic hepatitis B with acute exacerbation, the entecavir is designed for induction (12–26 days) until ALT levels decline to 5–10 × ULN and for transient combination (14 days after initiation of Pegasys) afterwards.