TET2 and chronic myelomonocytic leukemia: From our results, we may conclude: 1) CMML is associated with an abnormal epigenetic profile with 249 genes differentially hypermethylated; 2) CMML patients with mutations in TET2 showed a different methylation profile than patients wild type TET2, and these differences segregate CMML patients in 2 groups with an increase in hypermethylated genes in non-mutated patients; 3) although TET2 mutations induced a decrease in the content of 5 hmC, the analysis of specific genes and CpGs demonstrate a heterogeneous behavior in terms of 5 mC and 5 hmC content.