In particular, as TET2 mutations are by far the most frequently event in CMML patients [3] and as recent studies have demonstrated that reduced function of the TET2 protein leads to abnormal hematopoiesis and development of a CMML like disease in mice [9], [10], [11] it seems that TET2 protein plays an important role in the pathogenesis of CMML. Here, TET2 is linked to chronic myelomonocytic leukemia.