Although TET2-mut patients would be expected to show an increase in hypermethylation in comparison with TET2-wt (due to the lack of capacity to convert 5 hmC) [15] this was the case for only 13 of the differentially methylated genes while the majority (43 genes) showed an aberrant hypermethylation in TET2-wt CMML patients. This evidence concerns the gene TET2 and chronic myelomonocytic leukemia.