LYN and leukemia: Mice deficient for PLC-beta3 and Lyn develop a myelodysplastic/myeloproliferative neoplasm similar to human CMML [31], [32] which is dependent on a decrease in Shp-1 phosphatase activity and as a consequence a constitutive activation of Stat5, required for the development of leukemia and CMML-like syndrome [31].