The presence of hypermethylation of the CDKN2B in 58% of cases with CMML and hypomethylation of C-MYC in 2 patients has been previously reported [40], [41] and hypermethylation of 94 out of 807 genes in a small group of 14 CMML patients in comparison with normal controls [42] are some of the few studies reporting epigenetic changes in this disease. Here, MYC is linked to chronic myelomonocytic leukemia.