Based on the fact that a subgroup of CMML samples segregated with healthy control samples while the rest of CMML samples clustered separately in the second cohort (Figure 1 and Figure S2) we hypothesized that mutations of JAK2, EZH2, TET2, IDH1 or IDH2 could be implicated in the epigenetic regulation in CMML. This evidence concerns the gene IDH2 and chronic myelomonocytic leukemia.