EZH2 and chronic myelomonocytic leukemia: Based on the fact that a subgroup of CMML samples segregated with healthy control samples while the rest of CMML samples clustered separately in the second cohort (Figure 1 and Figure S2) we hypothesized that mutations of JAK2, EZH2, TET2, IDH1 or IDH2 could be implicated in the epigenetic regulation in CMML.