More than 80% of CMML patients harbor mutations in diverse genes including TET2, CBL, RUNX1, RAS, IDH1, IDH2, NPM1, ASXL1, NPM1 or EZH2[49] and although some of those mutations like EZH2 or TET2 have been associated with the prognosis of the disease their role is currently unclear [49]. This evidence concerns the gene RUNX1 and chronic myelomonocytic leukemia.