After 72 h of incubation, we observed increased levels of IFN-γ, TNF-α, IL-10, IL-2, and TGF-β1 in the supernatant of RB tumor cell and PBMC cultures incubated with 1 μg/ml of EpCAM×CD3 antibody compared to an incubation with CD3 or EpCAM monoclonal antibodies alone (Figure 18). This evidence concerns the gene IL2 and retinoblastoma.