The aim of this study was to investigate PINCH expression in tumours and its relationship to RT, clinical (gender, age, TNM stage, differentiation, local recurrence, distant recurrence and survival), pathological (lymph-angiogenesis, angiogenesis, inflammatory infiltration and necrosis) and biological factors (apoptosis) in rectal cancer patients with or without RT. This evidence concerns the gene LIMS1 and neoplasm.