GRIA2 and retinal degeneration: To study the kinetics of GluR2 expression and trafficking in retinal degenerative disease, we used the LIRD model, which contains the full spectrum of sequelae found in naturally occurring and engineered forms of retinal degeneration and remodeling, including early retinal stress, photoreceptor loss, Müller cell remodeling, neuritogenesis [8], and remodeling of all neural cell populations in the retina and formation of microneuromas [8,12].