Whether the same biological consequence of changes in IFN control will play out in the ferret, considered a more authentic model for human influenza, remains to be seen (Meunier & von Messling, 2011) although acquisition of CPSF-30 binding by pH1N1 NS1 mutations attenuated disease in ferrets as well as in mice (Hale et al., 2010c). Here, CPSF4 is linked to influenza.