TP53 and neoplasm: There is as yet no appropriate genetic model of HGSC that accurately recapitulates the p53 mutation and general genomic instability characteristic of this malignancy 6, but intraperitoneal injection of malignant cells in xenogeneic or syngeneic models generates large intraperitoneal tumours and ascites fluid with tumour growth usually measured by bioluminescent imaging of luciferase-transfected cells or weight of macroscopic resected tumours 7–10.