Circulating insulin levels decline in response to PH-induced hypoglycemia (and are augmented by dextrose supplementation [18]), and, interestingly, hepatocellular proliferation in models of toxin-induced liver injury is accelerated and augmented in mice with streptozotocin-induced insulin-deficient diabetes [29, 30]. This evidence concerns the gene INS and hyperinsulinemic hypoglycemia, familial, 4.