Our findings fit particularly well to murine and human ex vivo data suggesting pronounced PTX3 expression in advanced but not early atherosclerotic lesions.[12], [13] In the Bruneck Study, PTX3 was independently related to both carotid and femoral atherosclerosis and to manifest cardiovascular diseases mainly originating from unstable plaques (Figure 3). The gene discussed is PTX3; the disease is atherosclerosis.