It is expressed in monocytes, macrophages, endothelical cells, dentritic cells, fibroblasts and epithelial cells [4] – all of which are present in the vascular wall and increased in atherosclerotic plaques – and therefore a potential specific marker of inflammation and atherosclerotic changes of the vascular wall.[5]–[7] High PTX3 levels have been associated with unstable angina [8], adverse outcome after myocardial infarction [9] and heart failure [10]. The gene discussed is PTX3; the disease is heart failure.