Specifically, we showed that in a cohort of patients inheriting this CFHR5 nephropathy, the 1936C allele at the binding site for miRNA hsa-miR-1207-5p is associated with a less severe phenotype, as this is exemplified in patients who are protected from the development of high grade proteinuria and CKD (p = 0.018, Fig. 3). The gene discussed is CFHR5; the disease is chronic kidney disease.