STAT3 and non-small cell lung carcinoma: Depletion of JAK2 in NCI-H1703 cells—which demonstrate the highest levels of STAT3 and pSTAT3Y705 expression—results in a near complete loss of STAT3 phosphorylation comparable to ruxolitinib, supporting the hypothesis that JAK2 is the kinase primarily responsible for STAT3Y705 phosphorylation in NSCLC (Fig. 4C).