To address the importance of JAK2/STAT3 signaling in human tumor tissue samples, we performed immunohistochemistry (IHC) for JAK2, STAT3 and pSTAT3Y705 on a clinically annotated tissue microarray (Table S3) containing 245 stage I/II NSCLC samples (Fig. 4D). Here, STAT3 is linked to non-small cell lung carcinoma.