Flow cytometry analyses showed that CXCR3, mainly expressed by Th1 cells and CTL, was present on significantly fewer CD4+ and CD8+ LPL (p<0.01) in the tumor tissue compared to the unaffected tissue (Fig. 6), whereas in the case of Treg there was only a trend towards decreasing frequencies of CXCR3+ cells. This evidence concerns the gene CXCR3 and neoplasm.