IFNG and tuberculosis: We previously demonstrated that in contrast to vaccine-protected nonhuman primates, unvaccinated juvenile macaques infected with large-dose Mtb by aerosol exhibited delays for development and pulmonary trafficking of Ag-specific αβ and γδ T effector cells producing IFNγ, and developed profound inflammatory responses and severe TB lesions in lungs [8], [9], [11], [17].