We presented the following evidence to support this conclusion: (a) generation of Bezielle-induced ROS is greatly inhibited in the non-respiring Rho-0 tumor cells lacking mitochondria or in cells where mitochondrial respiration is chemically inhibited; (b) inhibition of mitochondrial respiration suppresses DNA damage and hyper activation of PARP induced by Bezielle; (c) inhibition of mitochondrial respiration strongly attenuates inhibition of glycolysis by Bezielle (d) the Rho-0 cells are resistant to Bezielle cytotoxicity. Here, PARP1 is linked to neoplasm.