In 2006, Del Campo et al. recognized that hemizygosity of the NCF1 gene as a result of the largest recognized WBS microdeletion—about 1.83 Mb—decreases the risk for hypertension in WBS patients compared to those possessing the more common smaller deletion (1.55 Mb) not incorporating NCF1 (Figure 1, top) [5]. The gene discussed is NCF1; the disease is hypertensive disorder.