REN and hypertensive disorder: Campuzano et al. observed that WBS mice called “DD”, with a 0.67 Mb deletion from Limk1 to Trim50 (that contains Eln), manifest a cardiovascular phenotype including hypertension with elevated angiotensinogen (Agt), renin (Ren), and angiotensin converting enzyme (Ace) mRNA throughout life (Figure 1, bottom) [7].