Interestingly, there are new reports of strains that form large, dense plaques and show prolonged incubation periods, such as vCJD prions in transgenic mice expressing human 129VV PrPC[52] and Gerstmann–Straussler-Scheinker (GSS) prions in TgPrP101LL mice [53]. Here, PRNP is linked to variant Creutzfeldt-Jakob disease.