BALB/c mice treated with either α-CTLA-4 (20/20; 100%) or α-PD-L1 (20/22; 90.9%) developed classical neurological signs of ECM and were euthanised on days 7–8 post-infection or days 8–10 post-infection, respectively, whereas control mice (treated with rat IgG or PBS) survived for up to two weeks and were euthanised due to severe anaemia (Figure 3A, B). This evidence concerns the gene CD274 and anemia.