As expected from its tumor suppressor role, KLF11 regulates a series of cancer-associated genes, including those for apoptosis (AKT1, TP53, CASP9), growth and migration (CXCR4, SIRT2), and epigenetic regulation (HDAC1, HDAC3, HDAC6), whereas other genes are less studied in this context. This evidence concerns the gene HDAC3 and cancer.