SIRT2 and cancer: As expected from its tumor suppressor role, KLF11 regulates a series of cancer-associated genes, including those for apoptosis (AKT1, TP53, CASP9), growth and migration (CXCR4, SIRT2), and epigenetic regulation (HDAC1, HDAC3, HDAC6), whereas other genes are less studied in this context.