As expected from its tumor suppressor role, KLF11 regulates a series of cancer-associated genes, including those for apoptosis (AKT1, TP53, CASP9), growth and migration (CXCR4, SIRT2), and epigenetic regulation (HDAC1, HDAC3, HDAC6), whereas other genes are less studied in this context. Here, HDAC1 is linked to cancer.