Notably, whereas KLF11 WT decreased tumor size compared with control (133.5 mm3 ± 25.9 mean tumor volume after 4 weeks for KLF11 WT versus 405.3 mm3 ± 16.6 for EV, p < 0.05), failure of HP1 recruitment (KLF11ΔHP1) impaired tumor suppressive activity (Fig. 8, E and F; 478.2 mm3 ± 24.1 mean tumor volume after 4 weeks). Here, KLF11 is linked to neoplasm.