In conclusion, this study systematically analyzed the roles of PinX1 in NPC 5-8 F cells by oeverexpression or downregulation of PinX1 and found that PinX1 affects NPC cell growth, migration, wound healing ability and cell cycles by inhibiting telomerase activity, suggesting that PinX1 is a potential telomerase inhibitor and has potential therapeutic application in treatment of tumors including NPC. The gene discussed is PINX1; the disease is nasopharyngeal carcinoma.