PINX1 and Familial prostate cancer: For example, studies [14] on 159 cases of hereditary prostate cancer identified 39 polymorphisms during PinX1 sequencing; studies [15] on gastrointestinal cancer also found a missense mutation (AGC/TGC) out of 254 codons in 1 case of colon cancer and 1 case of esophageal cancer.