Such proportions of IFNγ-producing cells are very high compared to the results presented here in all groups of subjects regardless of the presence of infection: 2.43% in acute and 6.64% in severe malaria vs. 0.22% in controls, and might reflect the heterogeneity of innate immune responses between donors, and/or populations [30,38] with crucial influencing factors such as type of nutrition [39], among other. The gene discussed is IFNG; the disease is infection.